Peroxsil® inhibits fungi through its ability to generate reactive oxygen species (ROS), which cause widespread oxidative damage to cellular membranes, proteins, and nucleic acids. This is a non-specific mechanism on multiple levels that results in the overall disruption of cellular integrity and function, leading to fungal cell death.
Cellular Effects of Peroxsil®
Leads to the formation of lipid radicals, which propagate chain reactions and result in membrane damage, loss of membrane fluidity, and disruption of membrane-bound proteins.
Oxidizes amino acid residues, leading to the formation of carbonyl groups and cross-linking of proteins, which can alter enzyme activity, structural integrity, and signalling pathways.
Causes strand breaks, base modifications, and cross-linking in DNA. This can result in mutations, impaired replication, and transcription, and potentially lead to carcinogenesis
Functions as signalling molecules regulating processes like cell proliferation, differentiation, and apoptosis. They modulate the activity of kinases, phosphatases, and transcription factors.
Interacts with thiol groups (-SH) in proteins and enzymes on the fungal cell membrane. This interaction disrupts membrane integrity by causing structural changes and increased permeability.
Disrupts membrane integrity leads to the leakage of cellular components and ions, disrupting the fungal cell’s homeostasis and vital functions.
Binds to and inhibits essential enzymes involved in fungal metabolism and replication. This interference disrupts cellular processes necessary for fungal growth and survival.
Induces the production of ROS within fungal cells causing oxidative damage to proteins, lipids, and DNA, leading to cellular dysfunction and death.
Binds to nucleic acids and disrupt DNA replication and repair processes in fungal cells. This leads to genetic mutations, cell cycle arrest, and eventual cell death.
Inhibits the germination of fungal spores, preventing the establishment of new infections or the spread of existing ones.
Hinders the elongation and growth of fungal hyphae, crucial for fungal colonization and propagation.
Conclusion: Peroxsil® combats fungi in multiple ways, making it highly effective.
